Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ
نویسندگان
چکیده
http://sro.sussex.ac.uk Kampmann, Beate, Hemingway, Cheryl, Stephens, Alick, Davidson, Robert, Goodsall, Anna, Anderson, Suzanne, Nicol, Mark, Schölvinck, Elisabeth, Relman, David, Waddell, Simon J, Langford, Paul, Sheehan, Brian, Semple, Lynn, Wilkinson, Katalin A, Wilkinson, Robert J et al. (2005) Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-γ. Journal of Clinical Investigation, 115 (9). pp. 2480-2488. ISSN 0021-9738
منابع مشابه
Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma.
Genetic defects in the IFN-gamma response pathway cause unique susceptibility to intracellular pathogens, particularly mycobacteria, but are rare and do not explain mycobacterial disease in the majority of affected patients. We postulated that acquired defects in macrophage activation by IFN-gamma may cause a similar immunological phenotype and thus explain the occurrence of disseminated intrac...
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BACKGROUND The clinical syndrome of disseminated nontuberculous mycobacterial (NTM) infection in patients who were previously healthy is now well recognized to be associated with an acquired autoantibody to Interferon gamma (Anti IFN- γ autoantibody). However, the risk factors of this syndrome remain unknown. METHOD We performed an unmatched case control study among patients with NTM diseases...
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Adult patients with disseminated nontuberculous mycobacterial (dNTM) infections usually have severe immune system defects. Recently, several studies have shown that anti-IFN-γ autoantibodies may play an important role in the pathogenicity of dNTM infections. A considerable proportion of reported cases of anti-IFN-γ autoantibodies show either clinical or laboratory evidence of autoimmune disease...
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Disseminated non-tuberculous mycobacterium (dNTM) infection is rare in humans without human immunodeficiency virus (HIV) infection. Previous reports have shown autoantibodies to human interferon-gamma (IFN-γ), which play important roles in mycobacterium infection, in the sera of patients with non-HIV dNTM disease. Herein, we describe a 53-year-old male who was strongly suspected to have multice...
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